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Impact of cellular morphology and three-tiered nuclear grade on progression of conventional renal cell carcinoma
  1. Lilla Domonkos1,
  2. Maria Yusenko2,
  3. Gyula Kovacs3,
  4. Lehel Peterfi1
  1. 1 Department of Urology, University of Pecs Medical School, Pecs, Hungary
  2. 2 Institute of Human Genetics, Ruhr-University, Bochum, Germany
  3. 3 Laboratory of Molecular Oncology, Medical Faculty, Ruprecht-Karls-University, Heidelberg, Germany
  1. Correspondence to Professor Gyula Kovacs, Laboratory of Molecular Oncology, Medical Faculty, Ruprecht-Karls-University, Heidelberg, Germany; gyula.kovacs{at}urz.uni-heidelberg.de

Abstract

Aims and methods The aims of this study were to evaluate the prognostic impact of cytomorphology and three-tiered grading on tumour-free survival of patients with conventional renal cell carcinoma (cRCC). Formalin-fixed, paraffin-embedded samples from 710 patients were assessed and the results were evaluated according to the clinical data.

Results Kaplan-Meier regression model showed that 90.9% of patients with clear cell, and 50.9% with pure eosinophilic cRCC were free of metastasis during follow-up. The three-triered grading showed a good correlation with progression as 95.2% of patients with of G1 tumours, 66.1% with G2 tumours and only 25.3% with G3 tumours were tumour free (p<0.001). The grading was correlated with cytomorphology and coagulation necrosis. In multivariate analysis, tumour grade and stage were independent prognostic markers (p<0.001).

Conclusions The three-tiered grading predicts the progression of cRCC irrespectively of cytomorphology. However, the cytomorphology and necrosis show a good correlation with three-tiered grading in estimate disease progression.

  • Histology
  • Morphological and Microscopic Findings
  • Urologic Neoplasms
  • Kidney Neoplasms

Data availability statement

Dataset of tumour characteristics is available from the corresponding author on reasonable request.

https://doi.org/10.1136/jcp-2023-209094

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    Data availability statement

    Dataset of tumour characteristics is available from the corresponding author on reasonable request.

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    Footnotes

    • Handling editor Murali Varma.

    • Contributors All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by LD and GK. Collection of clinical data was performed by LP. The statistical analysis was performed by MY. The first draft of the manuscript was written by LD and LP and the final version was reviewed by MY and GK. All authors read and approved the final manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.